Graduated from the Odessa I. I. Mechnikov National University with a degree in Classical Philology. Throughout different episodes of her career she was leading numerous institutions: Moscow Center of Arts at Neglinnaya, Tatintsian Gallery and Museum and Exhibition association of "Manege", D. A. Nalbandyan's museum-studio space and museum of V. A. Sidur. Co-founder of the Proun Gallery and a member of the experts council (2010) and the jury (2014) for the Kandinsky Prize awards. Marina Loshak was appointed director of the Pushkin State Museum of Fine Arts on July 1, 2013.
Maintaining the tradition established by the founder of the Museum Ivan Tsvetaev, she develops a large project Pushkin Museum XXI aiming to show the interaction between the classical and contemporary art through temporary exhibitions, including October by Cai Guo-Qiang (2017) Fabrizio Plessi, The Soul of Stone (2018), There is a Beginning in the End (2019, Venice), Odd Convergences (2021-2022) and many others.
In 2017 the Pushkin Museum participated in the Venice Biennale for the first time with the exhibition Man as Bird. Images of Travel. Marina Loshak pursues development of strong international connections, enabling to hold large exhibitions such as Renaissance Venice. Titien, Tintoretto, Veronese (2017), The Age of Rembrandt and Vermeer. Masterpieces from the Leiden Collection (2018), Picasso & Khokhlova (2018–2019), Collection of Fondation Louis Vuitton. Selected works (2019), Thomas Geighsboro (2019-2020).
Marina Loshak also gives high priority to the topic of collecting. In 2019, unprecedented in scales and contents exhibition Shchukin. Biography of a Collection was held at the Museum. It presented the history of the formation of Sergey Shchukin’s collection via his personality, the biography of his family as well as the cultural and historical context. The collection was divided in 1948 between Moscow and Leningrad and reunited at the exhibition in the Pushkin State Museum of Fine Arts. It was the most exciting event for Russian culture. Brother Ivan. Mikhail and Ivan Morozov’s Art Collections exhibition was the continuation of the story about the great dynasties of Moscow collectors. It was held in the Pushkin Museum in 2022. The influential family of the industrialists Morozovs gave Russia two collectors of contemporary arts at once in the end of the 19th century. The exhibition reconstructs the collections of French and Russian paintings assembled by the brothers Ivan and Mikhail Morozov.
Active development of online activities under Marina Loshak's direction resulted in several important multimedia projects: educational platform The Pushkin Academy dedicated to art history and major artworks from the museum's collection; 100 Ways to Live a Minute where people who create and reflect on art share their experiences of meaningful living of time; The Other War: the project dedicated to the 75th anniversary of victory in the Great Patriotic War presenting the life of the Museum from 1941 to 1945; #НаединесПушкинским (#AlonewithPushkin): the online program launched during the COVID-19 pandemic that combined all projects on the Internet; Red Vineyard at Arles (Montmajour): the project for the studies and conservation of the world famous picture by Vincent van Gogh; The Gold of Troy from the Pushkin State Museum of Fine Arts: the research project to study the Trojan collection of Heinrich Schliemann.