He began his career in the 1980s as a journalist and editor for the Novosti Press Agency, or APN (now the Russian Agency of International Information "RIA Novosti") before transitioning into book publishing in the late 1980s. In 1992, he set up his own publishing house, Vagrius, one of the most prominent publishing houses in post-Soviet Russia. In the mid-1990s, he founded Premier Film where, as President of the company, he produced a number of films for television and cinema, as well as arts programmes for TV.
In 1999, Mr. Grigoriev began his career in the civil service. In 1999–2004 he was a Deputy Minister of the Russian Federation for Press, Broadcasting and Mass Media. In 2008: he was appointed Deputy Head of the Russian Federal Agency for Press and Mass Communications. He is also Chairman of the Board of Trustees of the Russian National Big Book Literary Prize, President of the Centre for the Support of Language Arts in Russia, Chairman of the Organising Committee of the Moscow International Book Fair and Council Chairman of the "Russian-Polish Center for Dialogue and Understanding" Foundation. Mr. Grigoriev is the recipient of Russian, Polish and French state awards. In 2001 he was awarded the Russian State Prize for Literature and Arts.